Methotrexate Side Effects: Review Article
نویسندگان
چکیده
Side effects of MTX high dose (MTX-HD) may be life threatening, however those of various doses of oral MTX are variable because of the interindividual variability of gastrointestinal absorption of this drug. Bone marrow, gastrointestinal mucosa and hair are particularly vulnerable to the effects of MTX, secondary to their high rate of cellular turnover [2] and because MTX concentration is inversly proportianal to renal clearance [2], renal toxicity is frequent with MTX-HD.
منابع مشابه
Side effects and management of side effects of methotrexate in rheumatoid arthritis.
Low-dose methotrexate (MTX) remains the first-line treatment option among the disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. However, diverse side effects are the major reason for MTX withdrawal and change of treatment. The following article reviews the published data on general and organ-specific side effects and outlines the current recommendations addressing pre...
متن کاملبررسی نتایج بیوپسی کبد در بیماران مبتلا به پسوریازیس تحت درمان متوترکسات
Objective: To assess Methotrexate-related side effects on the liver. Patients & methods: 45 liver biopsies were examined in dermatology ward of Loghman-e-Hakim Hospital in 1986-91.27 liver biopsies were examined after treatment with Methotrexate and were comparisoned with 27 liver biopsies which were not treated with Methotrexate. Results: Among 27 liver biopsies which were treated with...
متن کاملCombination chemotherapy with Methotrexate, Fluorouracil and Leucovorin in advanced Mycosis Fungoides
Background: Mycosis fungoides (MF) is a cutaneous T cell lymphoma. There are only palliative treatments in advanced stages with no cure. Most chemotherapy regimens have temporary effects with various side effects. Objective: The objective of this study was to assess the efficacy of a new chemotherapy regimens in advanced stages of MF. This regimens takes advantage of synergistic effect of metho...
متن کاملهپاتوتوکسیسیتی متوتروکسات؛ خطری که نباید نادیده گرفته شود: معرفی 4 بیمار و مرور مطالب کاربردی
Introduction: Methotrexate is used increasingly for treatment of some diseases such as rheumatoid arthritis, psoriasis and Crohn. Bone marrow suppression, mucocutaneous lesions, pneumonitis, and hepatotoxicity are major side effects of this drug. Since methotrexate toxicity is dose dependent and is usually administered with low dose via a weekly regimen, its side effects are not commonly seen. ...
متن کاملP-161: Deleterious Side Effects of Methotrexate on In Vitro Fertilization and Protective Role of Cornus Mas Extract in Adult Mice
Background: Because of stress oxidative side effect of MTX on reproductive system, current study was aimed to evaluate protective effects of cornus mas fruit extract (CMFE) in mice treated with methotrexate (MTX). Materials and Methods: 48 young mature male mice were classified in 4 groups. Control group received only normal saline orally (0.2 ml/day), and the second group was administered MTX ...
متن کامل